Requirement for age-specific peak cortisol responses to insulin-induced hypoglycaemia in children

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Requirement for age-specific peak cortisol responses to insulin-induced hypoglycaemia in children.

OBJECTIVE Based on adult data, a peak cortisol response ≥500 nmol/l to insulin-induced hypoglycaemia constitutes a normal. Age-specific reference ranges for basal morning cortisol have been developed for clinical use in the paediatric population. Such reference ranges are not clearly established for peak cortisol responses to insulin-induced hypoglycaemia despite limited data suggesting an effe...

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Cortisol and growth hormone responses to spontaneous hypoglycaemia in infants and children.

AIMS To evaluate responses of cortisol and growth hormone (GH) to spontaneous hypoglycaemia in infants and children. METHODS Retrospective review of laboratory and clinical data in paediatric patients investigated for suspected hypoglycaemia over a five year period. Thirty patients (16 aged <3 months) had hypoglycaemia confirmed by laboratory analysis (glucose <2.5 mmol/l) and were compared w...

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Decreased cortisol response to insulin induced hypoglycaemia in asthmatics treated with inhaled fluticasone propionate.

AIMS To assess adrenal function in asthmatic children treated with inhaled fluticasone propionate for up to 16 weeks. METHODS Children with asthma and bronchial hyperresponsiveness to inhaled methacholine were treated with inhaled fluticasone 250-750 microg/day via Volumatic spacer. The insulin tolerance test (ITT) was performed to assess adrenal function. RESULTS Eighteen asthmatic patient...

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Early blunted cortisol response to insulin induced hypoglycaemia in familial Mediterranian fever.

OBJECTIVE To study cortisol, adrenocorticotropic hormone and C-reactive protein responses to specific stimuli in familial Mediterranean fever (FMF). METHODS For the purpose of measuring cortisol, ACTH, and CRP responses to insulin induced hypoglycaemia during attack-free periods, 14 FMF patients, 11 patients with ankylosing spondylitis or Behçet's disease as disease controls (DC), and a furth...

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Insulin induced hypoglycaemia in migraine.

Insulin induced hypoglycaemia produced migrainous symptoms in only two of 20 migraine sufferers and in none of a matched control group. The relationship of fasting and blood sugar levels to migraine attacks is discussed.

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ژورنال

عنوان ژورنال: European Journal of Endocrinology

سال: 2013

ISSN: 0804-4643,1479-683X

DOI: 10.1530/eje-13-0084